Difference between Office 2016 vs Office 365:

The short version: Office 2016 is the newest version of the Office productivity suite (Word, Excel, PowerPoint, etc), typically accessed via the desktop. Office 365 is a cloud-based subscription to a suite of programs including Office 2016. This means you have a few options for purchasing Office 2016: a stand-alone product or as part of an Office 365 subscription.

If you're looking to purchase Microsoft Office for your business, you've got plenty of options. But understanding difference between the options - most notably between Office 2016 and Office 365 - can be confusing.